Salsprin Injection, 100mL
Anti-inflammatory
KD13.500
Out of stock
Sodium salicylate produces irreversible inhibition of the cyclo-oxygenase step of arachidonic acid metabolism, leading to a suppression of prostaglandin production in all metabolic systems. The duration of action allows a twelve hour dosage regime for inflammatory conditions. Thrombosis inhibition requires administration every 2 – 7 days, depending on the dose.
SALSPRIN is indicated for the control of fever and/or pain, as well as for control of inappropriate thrombosis in the horse and dog. Salicylate has a half-life of 1 hour in the horse, and 8.6 hours in the dog,and is rapidly cleared from the body. Onset of action is approximately 10 – 15 minutes. The pharmacological effects of the salicylate are, however,considerably more prolonged than this, due to the irreversible nature of the action. This allows a 12 hour dosing regime for inflammatory conditions. SALSPRIN will not control severe visceral pain, or sharp or excruciating pain due to severe wounds or fractures. Musculo-skeletal: Short term treatment of mild joint and connective tissue disease, osteoarthritis, tendon and ligament sprains, and exertional myopathy. Pyrexia: Symptomatic suppression of fever in situations where the pyrexia is inappropriate or excessive. Thrombosis: Prevention or reduction of thrombosis when it plays a part in disease aetiology (such as pedal thrombotic conditions), early disseminated intravascular coagulation -DIC- in horses and dogs, and as an adjunct to Dirofilaria immitis adulticide therapy in dogs.
Dosage And Administraion : Anti-inflammatory Effect:
-Horse: 35 – 45 mg/kg every 8 – 12 hours by slow intravenous injection
Dogs: 10 mg/kg every 12 hours by slow intravenous injection
Contraindications :
-SALSPRIN should not be administered to animals less than 30 days old, or to animals with severe renal or hepatic disease.
-SALSPRIN should not be administered less than 7 days before surgery, or to those animals known to suffer from clotting defects.
-Do not use when intestinal ulceration is suspected or has been diagnosed.
-Do not use concurrently with aminoglycoside antibiotics.
-Administer by slow intravenous injection. Avoid extravasation as irritation and phlebitis may result.
Meat Withholding Period (Horses): 28 Days.